2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-100050
    4-Hydroxymidazolam
    4-Hydroxymidazolam is a major metabolite of Midazolam. Midazolam is a potent benzodiazepine with anxiolytic properties.
    4-Hydroxymidazolam
  • HY-113415
    Testosterone sulfate
    Testosterone sulfate is the metabolite of Testosterone. Testosterone is the main male sex hormone which determination is useful for assessment of androgen status.
    Testosterone sulfate
  • HY-W019726S1
    Dehydro Nifedipine-13C,d3
    Dehydro Nifedipine-13C,d3 is a deuterated labeled Dehydro Nifedipine. Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies.
    Dehydro Nifedipine-<sup>13</sup>C,d<sub>3</sub>
  • HY-W001080S1
    3,4-Dihydroxybenzeneacetic acid-d3
    3,4-Dihydroxybenzeneacetic acid-d3 is deuterium-labeled 3,4-Dihydroxybenzeneacetic acid (HY-W001080).
    3,4-Dihydroxybenzeneacetic acid-d<sub>3</sub>
  • HY-161481
    Melamine/bov igG
    Melamine/bov igG is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Melamine/bov igG
  • HY-33914R
    4-Hydroxymethylpyrazole (Standard)
    Callistephin (chloride) (Standard) is the analytical standard of Callistephin (chloride). This product is intended for research and analytical applications. Callistephin (Pelargonidin 3-O-glucoside) chloride is an anthocyanin that can be found in strawberries and chokeberries.
    4-Hydroxymethylpyrazole (Standard)
  • HY-143968S
    Ketotifen impurity 3-d4
    Ketotifen impurity 3-d4 is the deuterium labeled Ketotifen impurity 3.
    Ketotifen impurity 3-d<sub>4</sub>
  • HY-12771S1
    O-desmethyl Mebeverine acid-d5 hydrochloride
    O-desmethyl Mebeverine acid-d5 (hydrochloride) is the deuterium labeled O-desmethyl Mebeverine acid.
    O-desmethyl Mebeverine acid-d<sub>5</sub> hydrochloride
  • HY-12770S
    Mebeverine alcohol-d5
    		≥98.0%
    Mebeverine alcohol-d5 is the deuterium labeled Mebeverine alcohol, which is a metabolite of Mebeverine.
    Mebeverine alcohol-d<sub>5</sub>
  • HY-148642
    12-Hydroxynevirapine
    12-Hydroxynevirapine (12-hydroxy-NVP; 12-OH-NVP) is a major oxidative metabolite of Nevirapine (HY-10570). Nevirapine is a non-nucleoside reverse transcriptase inhibitor indicated for the HIV-1 infections. Nevirapine causes idiosyncratic hepatotoxicity and mild-to-severe skin rashes. 12-Hydroxynevirapine, a non-reactive metabolite, can be bioactivated by sulphotransferases (SULTs) in the liver and skin, yielding the reactive species 12-Sulphoxy-nevirapine.
    12-Hydroxynevirapine
  • HY-G0021S1
    N-Desmethylclozapine-d8 hydrochloride
    		99.74%
    N-Desmethylclozapine-d8 (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist.
    N-Desmethylclozapine-d<sub>8</sub> hydrochloride
  • HY-133676S
    Mono(2-ethyl-5-oxohexyl) phthalate-d4
    Mono(2-ethyl-5-oxohexyl) phthalate-d4 is a deuterium labeled Mono(2-ethyl-5-oxohexyl) phthalate (HY-133676). Mono(2-ethyl-5-oxohexyl) phthalate is an oxidative metabolite of Di(2-ethylhexyl) phthalate (DEHP). Mono(2-ethyl-5-oxohexyl) phthalate may protective sperm DNA damage. Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking.
    Mono(2-ethyl-5-oxohexyl) phthalate-d<sub>4</sub>
  • HY-B1109R
    N-Acetylprocainamide (Standard)
    Cimetidine (hydrochloride) (Standard) is the analytical standard of Cimetidine (hydrochloride). This product is intended for research and analytical applications. Cimetidine (SKF-92334) hydrochloride is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine hydrochloride is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine hydrochloride has anti-cancer and anti-inflammatory activity.
    N-Acetylprocainamide (Standard)
  • HY-12772R
    Hydroxy Itraconazole (Standard)
    Levetiracetam (Standard) is the analytical standard of Levetiracetam. This product is intended for research and analytical applications. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent.
    Hydroxy Itraconazole (Standard)
  • HY-135392R
    N-Desmethyl Pimavanserin (Standard)
    Methyl 3,4-dihydroxybenzoate (Standard) is the analytical standard of Methyl 3,4-dihydroxybenzoate. This product is intended for research and analytical applications. Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect.
    N-Desmethyl Pimavanserin (Standard)
  • HY-B0602S
    (R)-(-)-O-Desmethyl Venlafaxine-d6
    (R)-(-)-O-Desmethyl Venlafaxine-d6 is the deuterium labeled (R)-(-)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
    (R)-(-)-O-Desmethyl Venlafaxine-d<sub>6</sub>
  • HY-W701814
    Mazindol metabolite-d4 hydrochloride
    Mazindol metabolite-d4 hydrochloride is the deuterium labeled 2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one hydrochloride (HY-W700741). 2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one hydrochloride is a metabolite of the anorectic agent Mazindol.
    Mazindol metabolite-d<sub>4</sub> hydrochloride
  • HY-157910
    (±)17(18)-EpETE methyl ester
    (±)17(18)-EpETE methyl ester is an analog of the eicosapentaenoic acid (EPA) metabolite (±)17(18)-EpETE.
    (±)17(18)-EpETE methyl ester
  • HY-108869R
    Fodipir (Standard)
    Malvidin (chloride) (Standard) is the analytical standard of Malvidin (chloride). This product is intended for research and analytical applications. Malvidin (chloride) is a bioactive compound isolated from grape. Malvidin shows cytotoxicity through the arrest of the G2/M phase of cell cycle and induction of apoptosis. Malvidin can be used for the research of cancer.
    Fodipir (Standard)
  • HY-135111
    4-Desmethoxy Omeprazole
    4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria.
    4-Desmethoxy Omeprazole
Cat. No. Product Name / Synonyms Application Reactivity